Table 2.
Single and multiparametric entropy values corresponding to benign and malignant breast tumors
| Benign tumor | Malignant tumor | p value | AUC | |
|---|---|---|---|---|
| MRI metrics | ||||
| ADC map values (× 10–3 mm2/s) | 1.89 ± 0.10 | 1.15 ± 0.03 | 0.0001 | |
| Ktrans (1/sec) | 0.27 ± 0.05 | 0.80 ± 0.32 | 0.005 | |
| Single parameter entropy | ||||
| Entropy T1 | 4.14 ± 0.11 | 4.66 ± 0.06 | 0.00008 | 0.72 (0.64–0.79) |
| Entropy T2 | 4.98 ± 0.12 | 5.42 ± 0.06 | 0.002 | 0.68 (0.59–0.75) |
| Entropy b0 | 4.44 ± 0.17 | 5.06 ± 0.09 | 0.002 | 0.67 (0.59–0.75) |
| Entropy b600 | 3.00 ± 0.20 | 3.77 ± 0.09 | 0.0009 | 0.67 (0.59–0.75) |
| Entropy ADC | 4.90 ± 0.12 | 5.40 ± 0.06 | 0.0004 | 0.70 (0.62–0.77) |
| Entropy post-contrast DCE (High spatial resolution) | 5.00 ± 0.10 | 5.54 ± 0.05 | 0.00001 | 0.75 (0.67–0.82) |
| Entropy PK-DCE Pre | 4.32 ± 0.12 | 4.65 ± 0.05 | 0.02 | 0.62 (0.54–0.70) |
| Entropy PK-DCE post (wash-in) | 4.89 ± 0.08 | 5.30 ± 0.05 | 0.00006 | 0.72 (0.64–0.79) |
| Entropy PK-DCE post (wash-out) | 4.90 ± 0.09 | 5.24 ± 0.04 | 0.00007 | 0.69 (0.60–0.76) |
| Multiparametric entropy | ||||
| TSPM entropy (all Parameters) | 7.06 ± 0.27 | 8.93 ± 0.17 | < 0.00001 | 0.82 (0.74–0.88) |
| TSPM entropy (PK-DCE) | 7.06 ± 0.27 | 8.92 ± 0.17 | < 0.00001 | 0.82 (0.74–0.88) |
| TSPM entropy (high spatial resolution DCE) | 6.74 ± 0.19 | 8.28 ± 0.12 | < 0.00001 | 0.82 (0.75–0.88) |
| TSPM entropy (DWI) | 6.66 ± 0.22 | 8.20 ± 0.15 | < 0.00001 | 0.78 (0.70–0.85) |
DWI diffusion-weighted imaging, ADC apparent diffusion coefficient, PK pharmacokinetic, DCE dynamic contrast enhancement, FOS first order statistics, TSPM tissue signature probability matrix