Table 1.
Univariate logistic regression analyses for hormonal control defined as GH ≤ 2.5 µg/L and IGF-1 levels within normal ranges
| Number of patients | Odds ratio [95% CI] | p-Value | |
|---|---|---|---|
| Baseline | |||
| Age (per 10-year higher age) | 88 | 2.20 [1.39; 3.48] | < 0.001 |
| Sex (women vs men) | 88 | 2.87 [1.13; 7.33] | 0.027 |
| BMI (≥ 25 vs 20–25 kg/m2) | 88 | 0.50 [0.20; 1.26] | 0.139 |
| GH (per 1-μg/L lower level) | 88 | 1.01 [0.98; 1.04] | 0.433 |
| IGF-1 (per 50% lower level ULN) | 88 | 1.28 [1.01; 1.63] | 0.040 |
| TV (per 100-mm3 smaller size) | 88 | 1.02 [1.00; 1.05] | 0.055 |
| Week 12 | |||
| GH (per 1-μg/L lower level) | 84 | 3.86 [1.87; 7.98] | < 0.001 |
| IGF-1 (per 50% lower level ULN) | 85 | 10.70 [3.59; 31.91] | < 0.001 |
| TV (per 100-mm3smaller size) | 85 | 1.04 [1.00; 1.08] | 0.046 |
| Change-from-baseline to week 12 | |||
| GH (per 10% increase) | 84 | 0.73 [0.59; 0.90] | 0.004 |
| IGF-1 (per 10% increase) | 85 | 0.48 [0.33; 0.68] | < 0.001 |
| TV (per 10% reduction) | 85 | 1.37 [0.99; 1.90] | 0.059 |
Factors in bold are statistically significant. Data are based on the number of patients with available data for each factor at each timepoint, and with p-values from Chi squared tests