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. 2020 Mar 5;11:274. doi: 10.3389/fimmu.2020.00274

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Copyright © 2020 Nafia, Toulmonde, Bortolotto, Chaibi, Bodet, Rey, Velasco, Larmonier, Cerf, Adam, Le Loarer, Savina, Bessede and Italiano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IDO1 is expressed in human sarcoma and its tumor microenvironment. (A) Immunohistochemical staining for IDO1 in a cases with positive tumor cells (#1), immune cells (#2) or no positivity (#3). Stainings for CD8 in sequential sections are shown. (B) Quantification of IDO1 positivity within the total cohort (n = 203), patients harboring either high (CD8^High, n = 101) or low (CD8^Low, n = 101) CD8 infiltration. Data are represented as percentage. **p < 0.01.