Figure 3.

Intratumoral activity of the KP in several syngeneic mouse models. Four different syngeneic mouse models—CT26 colon cancer, A20 lymphoma, EMT6 breast cancer, and MCA205 sarcoma—were processed at an average tumor volume of 200 mm³, for non-tumor (contralateral) and intratumoral microdialysis. Collected microdialysates were then processed for simultaneous measurement of Kynurenine and Tryptophan content by LC/MS; Kynurenine to Tryptophan ratio was then calculated. For statistical analysis, student t-test was used. *p < 0.05, **p < 0.01, ***p < 0.001. Means ± SEM are represented.