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. 2020 Mar 5;11:274. doi: 10.3389/fimmu.2020.00274

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Copyright © 2020 Nafia, Toulmonde, Bortolotto, Chaibi, Bodet, Rey, Velasco, Larmonier, Cerf, Adam, Le Loarer, Savina, Bessede and Italiano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene expression assessment in tumor samples collected from a MCA205 tumor-bearing model treated or not with anti-PDL1. Tumor samples were retrieved 13 days post tumor inoculation, and subjected to RT-qPCR for expression analysis of genes encoding for the different enzymes of the KP and key inflammatory cytokines. On the right bottom, display of the p-values vs. the log transformed ratio of tumor mRNA level between PDL1 and Vehicle. Means ± SEM are represented. Ido1, Indoleamine 2,3 dioxygenase 1; Ido2, Indoleamine 2,3 dioxygenase 2; Tdo2, Tryptophan dioxygenase; Kynu, Kynureninase; Kyat1; Kynurenine Aminotransferase 1; Got2, Kynurenine Aminotransferase 4; Haao, Hydroxyananthranilate oxygenase; Kmo, Kynurenine Monooxygenase.