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. 2020 Mar 5;11:274. doi: 10.3389/fimmu.2020.00274

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Copyright © 2020 Nafia, Toulmonde, Bortolotto, Chaibi, Bodet, Rey, Velasco, Larmonier, Cerf, Adam, Le Loarer, Savina, Bessede and Italiano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Highlight of possible resistance mechanisms to IDO1 blockade through tumor gene expression profiling. (A) Volcano plot of NanoString gene expression analysis in tumor samples comparing GDC-0919 vs. Vehicle groups (left panel) and GDC-0919 + anti-PDL1 vs. anti-PDL1 (right panel). (B) Plot representation of p-value comparing GDC-0919 vs. Vehicle groups (X axis) and GDC-0919 + anti-PDL1 vs. anti-PDL1 (Y axis). Green dots indicate downregulations; Red dots indicate upregulations. Dashed line depicts a 0,05 significativity.