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. 2020 Mar 5;14:166. doi: 10.3389/fnins.2020.00166

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Copyright © 2020 Fleming, Dunn and Lowery.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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On-off and dual-threshold amplitude control, fixed 130 Hz frequency and 60 μs pulse duration. (A) On-off DBS amplitude controller. During simulation, the on-off controller increases or decreases the DBS amplitude by a fixed amount at each controller call, toward its upper or lower amplitude bounds, if the beta ARV is measured above or below the target value, the dotted red line in the beta ARV panel. (B) Dual-threshold amplitude controller. The dual-threshold controller uses a target beta ARV range, represented by the two dotted red lines. If the beta ARV is measured above the upper target range value or below the lower target range value the stimulation amplitude is increased or decreased, respectively, by a fixed amount toward the upper or lower bounds of the stimulation amplitude. If the beta ARV lies in the target range the stimulation amplitude remains constant.