Table 2.

PK parameters of dotinurad in plasma and urine on days 1 and 7 in the overproduction, underexcretion, and combination groups

Parameters	Treatment groups
	Overproduction (n = 6)	Underexcretion (n = 6)	Combination (n = 6)
Cmax (ng/mL)
Day 1	78.68 ± 14.92	83.80 ± 9.77	83.28 ± 10.22
Day 7	102.90 ± 21.43	101.20 ± 18.28	108.33 ± 15.49
Tmax (h)
Day 1	3.50 ± 0.55	4.00 ± 0.00	3.17 ± 0.41
Day 7	3.67 ± 0.52	3.17 ± 0.98	3.67 ± 0.52
T1/2 (h)
Day 1	11.67 ± 1.92	10.24 ± 1.32	11.37 ± 2.23
Day 7	11.49 ± 1.49	10.44 ± 0.66	10.83 ± 0.96
AUC0-inf (ng h/mL)
Day 1	1277.29 ± 490.68	1224.51 ± 197.78	1274.93 ± 155.18
Day 7	1688.49 ± 633.70	1561.90 ± 257.42	1688.15 ± 354.21
Cltot/F (L/h)
Day 1	0.86 ± 0.24	0.83 ± 0.14	0.79 ± 0.61
Day 7	0.64 ± 0.17	0.66 ± 0.11	0.61 ± 0.13
kel (1/h)
Day 1	0.0608 ± 0.0101	0.0686 ± 0.0089	0.0627 ± 0.0104
Day 7	0.0611 ± 0.0071	0.0666 ± 0.0043	0.0644 ± 0.0051
Vd/F (L)
Day 1	13.93 ± 2.59	12.14 ± 0.82	12.84 ± 1.64
Day 7	10.39 ± 1.94	9.81 ± 1.27	9.52 ± 1.75
MRT0-inf (h)
Day 1	17.68 ± 3.02	15.74 ± 2.00	16.77 ± 3.38
Day 7	16.78 ± 2.23	14.88 ± 1.09	15.53 ± 1.63

Data are presented as mean ± SD