Table 3.

PD parameters of serum uric acid in the overproduction, underexcretion, and combination groups

Parameters	Treatment groups			P valuea
	Overproduction (n = 6)	Underexcretion (n = 6)	Combination (n = 6)	Underexcretion/combination
ΔECmax (mg/dL)	− 4.60 ± 0.53	− 4.83 ± 0.35	− 5.88 ± 0.50
ΔAUEC0–24 (mg∙h/dL)
Day 1	52.90 ± 9.71	51.93 ± 7.38	71.72 ± 16.46	0.985/0.027*
Day 4	99.36 ± 11.20	105.69 ± 7.10	129.05 ± 12.91	0.501/< 0.001*
Day 7	99.73 ± 8.70	107.37 ± 9.38	127.98 ± 16.55	0.460/0.002*
Maximum reduction (%)	56.86 ± 6.80	55.75 ± 4.48	68.19 ± 7.70

Data are presented as mean ± SD

*P < 0.05 (vs overproduction group)

^aDunnett multiple comparison test was applied to the underexcretion group and the combination group, setting the overproduction group as the control group