Table 4.
PD parameters of urine uric acid levels in the overproduction, underexcretion, and combination groups
| Parameters | Treatment groups | P valuea | ||
|---|---|---|---|---|
| Overproduction (n = 6) | Underexcretion (n = 6) | Combination (n = 6) | Underexcretion/Combination | |
| Ae0–24 (mg) | ||||
| Day – 1 | 673.40 ± 85.52 | 516.25 ± 76.62 | 858.92 ± 108.63 | – |
| Day 1 | 1289.33 ± 126.45 | 1132.30 ± 104.21 | 1187.77 ± 104.29 | – |
| Day 2 | 951.45 ± 95.98 | 882.17 ± 132.88 | 829.33 ± 66.85 | – |
| Day 3 | 890.43 ± 82.41 | 804.60 ± 101.73 | 695.25 ± 75.70 | – |
| Day 4 | 838.15 ± 48.69 | 816.02 ± 98.22 | 616.40 ± 62.45 | – |
| Day 5 | 792.85 ± 91.37 | 758.12 ± 84.21 | 612.55 ± 64.36 | – |
| Day 6 | 810.43 ± 77.87 | 765.65 ± 110.89 | 619.17 ± 72.05 | – |
| Day 7 | 790.30 ± 58.99 | 760.50 ± 82.88 | 621.88 ± 92.18 | – |
| Day 8 | 483.35 ± 48.80 | 439.25 ± 65.28 | 438.77 ± 36.35 | – |
| CLR0–24 (mL/min) | ||||
| Day – 1 | 5.77 ± 0.64 | 4.14 ± 0.68 | 6.96 ± 1.33 | 0.017*/0.079 |
| Day 1 | 15.34 ± 2.21 | 12.50 ± 3.18 | 15.25 ± 4.93 | 0.361/0.999 |
| Day 4 | 14.92 ± 2.03 | 13.33 ± 1.75 | 13.86 ± 3.80 | 0.500/0.721 |
| Day 7 | 14.13 ± 2.23 | 12.60 ± 1.36 | 13.60 ± 3.53 | 0.490/0.909 |
| FE0–24 (%) | ||||
| Day – 1 | 4.77 ± 0.89 | 3.57 ± 0.64 | 4.93 ± 1.08 | 0.060/0.939 |
| Day 4 | 12.29 ± 2.04 | 11.04 ± 2.26 | 10.35 ± 2.10 | 0.511/0.232 |
| Day 7 | 11.76 ± 1.68 | 10.26 ± 1.51 | 10.25 ± 2.33 | 0.308/0.305 |
Data are presented as the mean ± SD
*P < 0.05 (vs overproduction group)
aDunnett multiple comparison test was applied to the underexcretion group and the combination group, setting the overproduction group as the control group