Fig. 3.

Conceptual approach to cell-specific targeted therapeutics delivery in treatment of cochlea-related diseases. The criteria necessary for targeted therapeutic delivery are represented in this image (see “Discussion” section). The TrkB receptor is specific to spiral ganglion tissue. The receptor has an accessible extracellular domain that allows for interaction with a targeted ligand (asterisk) and downstream therapeutic effects. Figure adapted with permission under the terms of the Creative Commons Attribution-Noncommercial (CC BY-NC 4.0) License. Pyykkö I, Zou J, Zhang Y, Zhang W, Feng H, Kinnunen P. Nanoparticle based inner ear therapy. World J Otorhinolaryngol 2013; 3(4): 114-133