Table 5.

Potential non-specific protein biomarkers

Protein	Gene	Cell type	Function	Targeting	Ref
Aquaporin 4	AQP4	Deiters’ and Hansen’s cells	Channel	None	[57]
ATP-sensitive inward rectifier K channel 10	KCNJ10	SV, SG Deiters’	Channel	None	[58, 59]
Basigin	BSG	SV, auditory nerve	Maintenance protein	None	[60]
CD44 antigen	CD44	Outer pillar and Claudius cells	Hyaluronic acid receptor	None	[61]
Clarin 1	CLRN1	OHC, IHC ,SG	Structural protein	None	[62, 63]
Fibroblast growth factor receptor 3	FGFR3	OHC, pillar and Deiters’ Cells	Growth factor	None	[64]
High affinity nerve growth factor receptor	NTRK1	OHC, IHC , SG supporting cell	Receptors	Peptide	[65, 66]
L-type calcium channel	CACNA1C CACNB1	Ubiquitous	Calcium channel	Peptides, Small Molecules	[67–69]
Otoancorin	OTOA	Spiral limbus, tectorial membrane,	Anchoring protein	None	[70]
Pendrin	SLC26A4	Sulcus, spiral prominence	Ion transport	None	[71, 72]
Synaptophysin	SYP	OHC, IHC, SG	Synapse protein	None	[73]
T-type calcium channel	CACNA1H CACNA1G CACNA1I	Ubiquitous	Calcium channel	Peptides, Small Molecules	[67, 74]
Transient receptor potential cation channel subfamily V member 4	TRPV4	SG,SV Support cells	Calcium channel	Small molecules	[75–77]
Type II transmembrane serine protease	HPN	SG,SV	Protease	Small molecule	[78–80]
Vang-like protein 2	VANGL2	OHC, IHC, supporting cells	Anchoring protein	None	[81]
Zinc transporter ZIP8	SLC39A8	Mainly OHC, IHC, SV, supporting cells	Transport protein	None	[82]
Zinc transporter ZIP14	SLC39A14	Mainly OHC, IHC, SV, supporting cells	Transport protein	None	[82]