Table 3.

The relative levels of Aβ and tau in different hippocampal sublayer in the 18‐month CD‐1 mice

Proteins		Regions	H‐LPS mice			L‐LPS mice			CON mice
			All mice	Males	Females	All mice	Males	Females	All mice	Males	Females
Aβ	DG	GL	0.057 ± 0.005	0.061 ± 0.007	0.053 ± 0.007	0.051 ± 0.003	0.049 ± 0.004	0.053 ± 0.005	0.050 ± 0.003	0.050 ± 0.004	0.050 ± 0.005
		HL	0.036 ± 0.002*	0.032 ± 0.003	0.038 ± 0.003*	0.029 ± 0.002	0.027 ± 0.002	0.031 ± 0.002	0.026 ± 0.002	0.027 ± 0.002	0.025 ± 0.002
		MS	0.043 ± 0.002*	0.043 ± 0.003*	0.043 ± 0.003*	0.040 ± 0.001*	0.038 ± 0.002	0.043 ± 0.002*	0.035 ± 0.002	0.035 ± 0.002	0.035 ± 0.002
	CA1	MS	0.032 ± 0.002*	0.033 ± 0.003	0.031 ± 0.003	0.028 ± 0.001	0.028 ± 0.001	0.028 ± 0.001	0.027 ± 0.001	0.026 ± 0.001	0.027 ± 0.002
		RS	0.044 ± 0.001*	0.044 ± 0.002	0.044 ± 0.002*	0.039 ± 0.001	0.040 ± 0.001	0.038 ± 0.001	0.038 ± 0.001	0.038 ± 0.001	0.037 ± 0.001
		PL	0.085 (0.077, 0.095)*	0.084 (0.077, 0.091)	0.088 (0.079, 0.097)*	0.079 (0.073, 0.086)	0.082 (0.068, 0.091)	0.077 (0.074, 0.079)	0.076 (0.071, 0.082)	0.079 (0.072, 0.082)	0.076 (0.072, 0.081)
		OS	0.035 ± 0.002	0.037 ± 0.003	0.034 ± 0.003	0.035 ± 0.001	0.034 ± 0.002	0.036 ± 0.002	0.034 ± 0.001	0.036 ± 0.002	0.032 ± 0.002
	CA3	MS	0.039 ± 0.002*	0.039 ± 0.002*	0.038 ± 0.002*	0.036 ± 0.001	0.034 ± 0.002	0.039 ± 0.001*	0.035 ± 0.001	0.036 ± 0.002	0.034 ± 0.001
		LS	0.045 ± 0.002* , †	0.043 ± 0.003	0.048 ± 0.003* , †	0.039 ± 0.003	0.041 ± 0.002	0.037 ± 0.002	0.036 ± 0.002	0.036 ± 0.002	0.037 ± 0.002
		PL	0.070 ± 0.004*	0.072 ± 0.006	0.069 ± 0.006*	0.065 ± 0.003	0.062 ± 0.003	0.069 ± 0.004*	0.058 ± 0.003	0.060 ± 0.003	0.055 ± 0.004
		OS	0.041 ± 0.002* , †	0.040 ± 0.003*	0.042 ± 0.003* , †	0.034 ± 0.002	0.034 ± 0.002	0.034 ± 0.002	0.032 ± 0.001	0.033 ± 0.002	0.032 ± 0.002
p‐tau	DG	GL	0.074 ± 0.002*	0.074 ± 0.002	0.074 ± 0.002*	0.070 ± 0.002	0.070 ± 0.002	0.069 ± 0.002	0.069 ± 0.002	0.071 ± 0.002	0.067 ± 0.002
		HL	0.041 ± 0.001*	0.041 ± 0.002	0.040 ± 0.002	0.037 ± 0.001	0.038 ± 0.002	0.037 ± 0.002	0.037 ± 0.001	0.037 ± 0.002	0.036 ± 0.002
		MS	0.043 ± 0.001* , †	0.044 ± 0.001* , †	0.042 ± 0.001*	0.039 ± 0.001	0.039 ± 0.001	0.040 ± 0.001	0.038 ± 0.001	0.037 ± 0.001	0.038 ± 0.001
	CA1	MS	0.036 ± 0.002* , †	0.038 ± 0.003*	0.035 ± 0.003	0.031 ± 0.002	0.032 ± 0.003	0.030 ± 0.003	0.028 ± 0.002	0.029 ± 0.003	0.027 ± 0.003
		RS	0.044 ± 0.001*	0.045 ± 0.002*	0.043 ± 0.002	0.043 ± 0.001*	0.044 ± 0.002*	0.042 ± 0.002	0.039 ± 0.001	0.038 ± 0.002	0.040 ± 0.002
		PL	0.100 ± 0.004*	0.099 ± 0.006*	0.100 ± 0.006	0.093 ± 0.004	0.095 ± 0.006	0.091 ± 0.006	0.086 ± 0.004	0.085 ± 0.006	0.087 ± 0.006
		OS	0.032 ± 0.002*	0.030 ± 0.002	0.033 ± 0.002*	0.030 ± 0.002*	0.030 ± 0.002	0.029 ± 0.002	0.024 ± 0.002	0.024 ± 0.002	0.025 ± 0.002
	CA3	MS	0.046 ± 0.003	0.047 ± 0.004	0.045 ± 0.004	0.042 ± 0.003	0.040 ± 0.004	0.043 ± 0.004	0.039 ± 0.003	0.039 ± 0.004	0.040 ± 0.004
		LS	0.049 ± 0.002*	0.048 ± 0.003	0.049 ± 0.003	0.043 ± 0.002	0.043 ± 0.003	0.044 ± 0.003	0.042 ± 0.002	0.043 ± 0.003	0.041 ± 0.003
		PL	0.078 (0.073, 0.090)*	0.078 (0.075, 0.082)	0.082 (0.072, 0.097)*	0.076 (0.067, 0.081)	0.076 (0.067, 0.080)	0.077 (0.067, 0.085)	0.067 (0.061, 0.081)	0.073 (0.053, 0.086)	0.068 (0.061, 0.077)
		OS	0.035 (0.026, 0.038)	0.037 (0.027, 0.038)	0.034 (0.021, 0.036)	0.033 (0.022, 0.036)	0.034 (0.025, 0.036)	0.030 (0.024, 0.035)	0.030 (0.022, 0.032)	0.027 (0.021, 0.035)	0.032 (0.027, 0.034)

Abbreviations: CON, control; H‐LPS, higher‐dose LPS; L‐LPS, lower‐dose LPS; LPS, lipopolysaccharide.

^*Compared to the control group, p < .05;

^†Compared to the low LPS group, p < .05.