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. 2020 Jan 30;10(3):e01546. doi: 10.1002/brb3.1546

Table 6.

The correlations between spatial performances and Aβ, p‐tau, and GFAP levels in different sublayer of hippocampus

Protein Ages Layers Groups Learning phase Memory phase
Number of errors (P) Latency (P) Number of errors (P) Latency (P)
Aβ 12‐month DG‐HL All mice 0.467 (0.011)* 0.441 (0.016)* 0.394 (0.092) 0.427 (0.045)*
H‐LPS 0.554 (0.048)* 0.553 (0.067) 0.284 (0.567) 0.325 (0.482)
DG‐MS All mice 0.192 (0.214) 0.317 (0.038)* 0.182 (0.244) 0.221 (0.154)
H‐LPS 0.328 (0.256) 0.265 (0.373) 0.083 (0.778) 0.123 (0.675)
18‐month DG‐HL All mice 0.451 (0.006)* 0.538 (0.004)* 0.320 (0.045)* 0.377 (0.018)*
H‐LPS 0.041 (0.807) 0.072 (0.663) 0.067 (0.827) 0.219 (0.472)
CA1‐RS All mice 0.234 (0.146) 0.326 (0.047)* 0.059 (0.706) 0.139 (0.575)
H‐LPS 0.062 (0.848) 0.081 (0.799) 0.482 (0.041)* 0.341 (0.234)
CA1‐PL All mice 0.318 (0.040)* 0.261 (0.096) 0.370 (0.021)* 0.473 (0.003)*
H‐LPS 0.626 (0.017)* 0.625 (0.018)* 0.119 (0.685) 0.286 (0.339)
22‐month DG‐HL All mice 0.375 (0.019)* 0.463 (0.003)* 0.370 (0.021)* 0.470 (0.003)*
H‐LPS 0.486 (0.049)* 0.542 (0.027)* 0.119 (0.685) 0.276 (0.339)
DG‐MS All mice 0.501 (0.015)* 0.507 (0.014)* 0.274 (0.206) 0.415 (0.049)*
H‐LPS 0.372 (0.086) 0.474 (0.028)* 0.020 (0.949) 0.278 (0.357)
L‐LPS 0.063 (0.905) 0.175 (0.740) 0.124 (0.815) 0.446 (0.031)*
CA1‐RS All mice 0.327 (0.044)* 0.254 (0.104) 0.334 (0.036)* 0.306 (0.049)*
H‐LPS 0.189 (0.556) 0.156 (0.627) 0.462 (0.049)* 0.082 (0.799)
CA3‐PL All mice 0.368 (0.015)* 0.411 (0.006)* 0.385 (0.011)* 0.365 (0.016)*
H‐LPS 0.027 (0.929) 0.021 (0.945) 0.162 (0.581) 0.142 (0.643)
p‐tau 12‐month DG‐MS All mice 0.388 (0.012)* 0.495 (0.001)* 0.310 (0.055) 0.377 (0.018) *
H‐LPS 0.488 (0.077) 0.631 (0.015)* 0.342 (0.277) 0.249 (0.434)
18‐month DG‐MS All mice 0.231 (0.136) 0.393 (0.007)* 0.320 (0.045)* 0.398 (0.005)*
H‐LPS 0.202 (0.507) 0.249 (0.412) 0.147 (0.631) 0.239 (0.432)
CA1‐RS All mice 0.016 (0.935) 0.123 (0.524) 0.063 (0.716) 0.069 (0.722)
H‐LPS 0.676 (0.018)* 0.137 (0.653) 0.263 (0.363) 0.154 (0.602)
L‐LPS 0.514 (0.047)* 0.024 (0.955) 0.405 (0.320) 0.179 (0.685)
22‐month DG‐MS All mice 0.338 (0.027)* 0.370 (0.015)* 0.365 (0.036)* 0.285 (0.064)
H‐LPS 0.016 (0.960) 0.453 (0.046)* 0.404 (0.029)* 0.090 (0.770)
CA1‐RS All mice 0.435 (0.022)* 0.426 (0.052) 0.041 (0.839) 0.413 (0.012)*
H‐LPS 0.613 (0.050) 0.619 (0.031)* 0.387 (0.192) 0.325 (0.135)
L‐LPS 0.569 (0.042)* 0.456 (0.017)* 0.348 (0.499) 0.348 (0.499)
CA1‐OS All mice 0.406 (0.068) 0.492 (0.035)* 0.473 (0.012)* 0.533 (0.065)
H‐LPS 0.467 (0.098) 0.556 (0.049)* 0.214 (0.701) 0.138 (0.769)
L‐LPS 0.316 (0.042)* 0.304 (0.559) 0.518 (0.036)* 0.327 (0.527)
CA3‐PL All mice 0.170 (0.301) 0.234 (0.151) 0.375 (0.020)* 0.352 (0.028)*
H‐LPS 0.320 (0.265) 0.219 (0.452) 0.484 (0.076) 0.464 (0.048)*
GFAP 12‐month CA3 All mice 0.393 (0.102) 0.423 (0.041)* 0.447 (0.416) 0.429 (0.311)
H‐LPS 0.091 (0.718) 0.065 (0.639) 0.453 (0.259) 0.321 (0.232)
18‐month CA1 All mice 0.348 (0.116) 0.362 (0.045)* 0.254 (0.104) 0.227 (0.149)
H‐LPS 0.266 (0.748) 0.281 (0.819) 0.156 (0.627) 0.189 (0.556)
CA3 All mice 0.561 (0.019)* 0.552 (0.023)* 0.232 (0.400) 0.282 (0.244)
H‐LPS 0.607 (0.041)* 0.621 (0.112) 0.162 (0.834) 0.113 (0.965)
22‐month DG All mice 0.405 (0.064) 0.492 (0.036)* 0.483 (0.032)* 0.543 (0.095)
H‐LPS 0.487 (0.095) 0.556 (0.089) 0.234 (0.701) 0.238 (0.766)
CA1 All mice 0.368 (0.015)* 0.411 (0.026)* 0.385 (0.091) 0.365 (0.106)
H‐LPS 0.027 (0.929) 0.021 (0.945) 0.265 (0.128) 0.142 (0.643)
CA3 All mice 0.397 (0.031)* 0.376 (0.029)* 0.475 (0.351) 0.395 (0.043)*
H‐LPS 0.432 (0.016)* 0.464 (0.017)* 0.196 (0.961) 0.324 (0.547)

Abbreviations: H‐LPS, higher‐dose LPS; L‐LPS, lower‐dose LPS; LPS, lipopolysaccharide.

*

p < .05.