Table 1.
Comparison of demographic and clinical data in patients with aSAH according to occurrence of delayed cerebral ischemia
| Characteristics | Total (n = 126) | DCI group (n = 46) | non‐DCI group (n = 80) | p value |
|---|---|---|---|---|
| Demographics | ||||
| Age, years | 53.4 ± 10.7 | 53.7 ± 9.3 | 53.3 ± 11.5 | .824 |
| Gender, female | 71 (56.3%) | 24 (52.2%) | 47 (58.8%) | .474 |
| Admission clinical finding | ||||
| SAP, mmHg | 146.1 ± 23.8 | 149.3 ± 27.3 | 144.3 ± 21.5 | .254 |
| DAP, mmHg | 83.8 ± 11.3 | 84.2 ± 9.9 | 83.6 ± 12.1 | .752 |
| MAP, mmHg | 104.6 ± 14.0 | 105.9 ± 14.3 | 103.8 ± 13.9 | .415 |
| WFNS grade | 3 (1–4) | 4 (3–5) | 1 (1–3) | <.001 |
| Grade I | 57 (45.2%) | 8 (17.4%) | 49 (61.3%) | |
| Grade II | 5 (4.0%） | 1 (2.2%) | 4 (5.0%) | |
| Grade III | 14 (11.1%） | 4 (8.7%) | 10 (12.5%) | |
| Grade IV | 29 (23.0%) | 15 (32.6%) | 14 (17.5%) | |
| Grade V | 21 (16.7%) | 18 (39.1%) | 3 (3.8%) | |
| Modified Fisher grade | 2 (2–3) | 3 (2–4) | 2 (2–2) | <.001 |
| Grade I | 9 (7.1%) | 2 (4.3%) | 7 (8.8%) | |
| Grade II | 67 (53.2%) | 13 (28.3%) | 54 (67.5%) | |
| Grade III | 27 (21.4%) | 15 (32.6%) | 12 (15.0%) | |
| Grade IV | 23 (18.3%) | 16 (34.8%) | 7 (8.8%) | |
| Diabetes mellitus | 14 (11.1%) | 4 (8.7%) | 10 (12.5%) | .513 |
| Smoking history | 34 (27.0%) | 15 (32.6%) | 19 (23.8%) | .281 |
| Aneurysm characteristics | ||||
| Aneurysm size, mm | 7.4 ± 0.4 | 7.3 ± 0.5 | 7.4 ± 0.4 | .934 |
| Multiple aneurysms | 37 (29.4%) | 11 (23.9%) | 25 (31.3%) | .629 |
| Anterior location | 94 (74.6%) | 35 (76.1%) | 59 (73.8%) | .772 |
| Surgical treatment | ||||
| Clipping | 105 (83.3%) | 42 (91.3%) | 63 (78.8%) | .069 |
| Coiling | 21 (16.7%) | 4 (8.7%) | 17 (21.3%) | |
| Ngb level, ng/ml | ||||
| Day 1 | 8.2 ± 2.9 | 9.9 ± 3.7 | 7.2 ± 1.5 | <.001 |
| Day 2 | 9.6 ± 3.0 | 11.2 ± 4.0 | 8.6 ± 1.7 | <.001 |
| Day 3 | 8.4 ± 1.9 | 9.5 ± 2.2 | 7.8 ± 1.3 | <.001 |
| Day 5 | 7.6 ± 1.8 | 8.5 ± 2.1 | 7.1 ± 1.4 | <.001 |
| Day 7 | 6.8 ± 1.5 | 7.5 ± 1.8 | 6.4 ± 1.2 | <.001 |
| Mean Ngba | 8.1 ± 2.0 | 9.3 ± 2.5 | 7.4 ± 1.1 | <.001 |
| Interactions | ||||
| WFNS grade × Ngb (day 1) | 24.2 ± 21.5 | 40.0 ± 25.2 | 15.1 ± 11.9 | <.001 |
| WFNS grade × Ngb (day 2) | 27.7 ± 24.0 | 44.4 ± 28.2 | 18.0 ± 14.2 | <.001 |
| WFNS grade × Ngb (day 3) | 23.7 ± 17.9 | 36.6 ± 18.7 | 16.3 ± 12.5 | <.001 |
| WFNS grade × Ngb (day 5) | 21.7 ± 16.7 | 33.0 ± 17.4 | 15.2 ± 12.3 | <.001 |
| WFNS grade × Ngb (day 7) | 19.2 ± 14.7 | 29.3 ± 15.6 | 13.3 ± 10.5 | <.001 |
| WFNS grade × mean Ngb | 23.3 ± 18.6 | 36.7 ± 20.5 | 15.6 ± 12.1 | <.001 |
Abbreviations: DAP, diastolic arterial pressure; MAP, mean arterial pressure; Ngb, neuroglobin; SAP, systolic arterial pressure; WFNS, World Federation of Neurosurgical Societies.
a
Mean Ngb value is the average of Ngb day 1, day 2, day 3, day 5, and day 7 Ngb values. Values are n (%), mean ± SD, and median (25%–75%).