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. 2020 Jan 21;10(3):e01526. doi: 10.1002/brb3.1526

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© 2020 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The effect of multiple stressors on the anxiety and depressive behaviors in adolescent mice. (a) The time spent in the central area in OFT tested in P41 adolescent mice of both sexes. RS significantly increases the time spent in the central area. (b) Same as (a) but separated by sex. RS significantly increases the time in males. (c) The percent time spent in open arms in EPM tested in adolescent mice of both sexes aged P42. No difference is seen among the four subgroups. (d) Same as (c) but separated by sex. No difference is seen among all subgroups in either males or females. (e) The percentage of immobility in FSTperformed in adolescent mice of both sexes on P51. All stressors significantly increase the percentage of immobility. (f) Same as (e) but separated by sex. In males, all stressors increase the percentage of immobility; in females, only MS increases it. Stars indicate the significance of the difference (*p < .05, **p < .01, ***p < .001, ****p < .0001)