Table 2.
Relationship between B7‐H5 expression and tumor pathology and prognosis
| Cancer type | Samples | B7‐H5 expression | Pathological correlates | Clinical outcomes | Refs |
|---|---|---|---|---|---|
| Pancreatic ductal adenocarcinoma | 136 | 68% (higha) | No correlation | Better OS | 17 |
| 32% (low) | |||||
| 92 | 77% (positiveb) | Highest expression in low‐grade pancreatic intra‐epithelial neoplasia (PanIN) | Better survival rate | 18 | |
| Lung cancer | 195 (cohort 1) | 61% (positive) | High TIL intensity and EGFR mutation status | Decreased OS (not statistically) | 19 |
| 197 (cohort 2) | 64% (positive) | ||||
| Osteosarcoma | 55 | 68% (positive) | High expression in metastatic tissue | Worse five‐year event‐free‐survival | 20 |
| Breast cancer | 50 | 56% (high) | Related to regional lymph node metastasis and advanced disease | Worse prognosis | 21 |
| Oral squamous cell carcinoma | 210 | 65% (high) | No correlation | Poor OS | 22 |
| Human clear cell renal cell carcinoma | 87 | Unclear | Related to larger tumor size and advanced TNM stage | Poor OS | 23 |
| 92 | 95% (positive) | Tumor size, clinical stage and histological grade | Poor OS | 24 | |
| Intrahepatic cholangiocarcinoma | 153 (cohort 1) | 49% high) | More likely to relapse and metastasize | Poor OS | 25 |
| 65 (cohort 2) | 68% (high) | ||||
| Bladder urothelial carcinoma | 212 | 84% (positive) | Significantly related to tumor stage, tumor size, tumor grade and lymph node metastasis | Poor OS and 5‐year recurrence‐free survival | 26 |
| 26% (high) | |||||
| Colorectal carcinoma | 63 | 48% (high) | Deeper infiltration depth | Poor OS | 27 |
| Glioma | 669 | Unclear | Low malignancy | Better OS | 28 |
| Gastric cancer | 124 | 53% (high) | Related to advanced clinical stages, deep tumor infiltration, lymph node metastasis and distant metastasis | Poor OS | 29 |
| 111 | 50% (high) | inversely related to the depth of tumor invasion, distant metastasis and disease stage | Higher 5‐year survival rate | 30 |
a
High: high B7‐H5 expression.
b
Positive: B7‐H5 express positive.
OS = overall survival; TNM = tumor–node–metastasis.