Table 1.
Identification of in vivo‐occurring ca‐IgG using mass spectrometry
| Diagnosis | Sex | Age | Location | Tissue | Protein group accessions | Sequence | Protein descriptions |
|---|---|---|---|---|---|---|---|
| RA | Female | 76 | Knee | Synovium | A0A087X130; A0A075B6H6 | HkVYAcEVTHQGLSSPVTK | Ig kappa chain C region |
| P01857; A0A087WYE1; A0A087WYC5 | KVEPkScDkTHTcppcpAPELLGGPSVFLFPPKPK | Ig gamma‐1 chain C region | |||||
| RA | Male | 56 | Hip | Synovium | A0A087X130; A0A087WZW8; A0A075B6H6 | HkVYAcEVTHQGLSSPVTK | Ig kappa chain C region |
| P01876 | TFTcTAAYPESkTPLTATLSK | Ig alpha‐1 chain C region | |||||
| A0A087X130; A0A087WZW8; A0A075B6H6 | VYAcEVTHQGLSSPVTkSFNRGEc | Ig kappa chain C region | |||||
| A0A087X130; A0A087WZW8; A0A075B6H6 | ADYEkHKVYAcEVTHQGLSSPVTK | Ig kappa chain C region | |||||
| A0A087WYE1; A0A087WYC5 | kVEPkScDKTHTcPpcpApELLGGPSVFLFPPKPK | Ig gamma‐1 chain C region | |||||
| P01861 | VDkRVESkYGppcpScpApEFLGGPSVFLFPPKPK | Ig gamma‐4 chain C region | |||||
| RA | Male | 49 | Knee | Synovial fluid | A0M8Q6 | VGVETTkpSkQSNNkYAASSYLSLTPEQWK | Ig lambda‐7 chain C region |
| RA | Male | 67 | Knee | Synovial fluid | A0M8Q6 | VGVETTkpSkQSNNkYAASSYLSLTPEQWK | Ig lambda‐7 chain C region |
Carbamylated immunoglobulins (ca‐IgG) detected in vivo in samples from rheumatoid arthritis (RA) patients, as analyzed by mass spectrometry, the carbamylated lysines are annotated (k); k = carbamyl, c = carbamidomethyl, p = oxidation.