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The antioxidant role of p53 signaling pathways in chemically induced oxidative stress (compiled from different cell types/lines and tissues): p53 activation can suppress the harmful effects of chemically induced intracellular ROS generation and oxidative stress. Chemicals cause p53-mediated antioxidant effects through a variety of mechanisms, including the activation of glutaminase 2 and GPX1, upregulation of sestrin2, and dephosphylation of JNK.
