Table 4.
Cox proportional hazard model of PBMC pyroptosis and 28-day mortality.
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Sex (age) | 0.686 | 0.240-1.957 | 0.481 | |||
| Age (year) | 0.978 | 0.944-1.014 | 0.224 | |||
| APACHE II score | 1.366 | 1.124-1.660 | 0.002 | 1.148 | 0.903-1.458 | 0.259 |
| Lymphocyte count | 3.731 | 0.178-78.132 | 0.396 | |||
| PBMC pyroptosis | 1.345 | 1.157-1.564 | ≤0.001 | 1.234 | 1.014-1.502 | 0.036 |
| IL-18 | 1.002 | 1.000-1.004 | 0.088 | |||
| IL-6 | 1.000 | 0.999-1.002 | 0.675 | |||
| PCT | 2.673 | 1.248-5.723 | 0.011 | 1.828 | 0.753-4.438 | 0.182 |
APACHE: acute physiology and chronic health evaluation; PBMCs: peripheral blood mononuclear cells; IL: interleukin; PCT: procalcitonin.