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. 2020 Feb 28;2020:6834236. doi: 10.1155/2020/6834236

Figure 5.

Figure 5

hKLK1 could activate PI3K/AKT/eNOS signaling in the corpus cavernosum of diabetic rats. Panels (a) and (b) show protein expressions of PI3K(p55), PDE5, and ICa-L normalized to β-actin level, and panels (c), (d), and (e) show the ratios of pAKT/AKT, PeNOS(S1177)/eNOS, and PeNOS(T495)/eNOS to evaluate their activity in all groups. Panels (f) and (g) show NO and cGMP levels normalized to total protein concentration of penile samples. Each bar represents mean ± standard error of the mean. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001. hKLK1: human tissue kallikrein 1; NO: nitric oxide; cGMP: cyclic guanosine monophosphate; WTR: wild-type rats; TGR: transgenic rats; WTDM: diabetic wild-type rats; TGDM: diabetic transgenic rats; TGDMH: diabetic transgenic rats administrated with HOE140.