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. 2020 Feb 29;2020:2390125. doi: 10.1155/2020/2390125

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Copyright © 2020 Cheng Chen et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

At-EE decreased IL-6 and VEGF production of ovarian cancer to inhibit angiogenesis. (a) SKOV3 was treated by At-EE for 48 h. Then, the mRNAs of IL-8, VEGF, FGF, MCP-1, OPN, and IL-6 were detected by real-time PCR. (b) SKOV3 was treated by At-EE for 48 h. Then, IL-6 and VEGF in conditioned media were detected by ELISA kits. (c) Wound healing assays were done for the mobility of HUVECs treated by condition media from ovarian cancer cells treated by At-EE in the presence or absence of IL-6, VEGF, or IL-6 and VEGF. (d) In vitro angiogenesis evaluation was done for HUVECs treated by condition media from ovarian cancer cells treated by At-EE in the presence or absence of IL-6, VEGF, or IL-6 and VEGF. The results were similar in at least three independent experiments. ^∗p < 0.05. ^∗∗p < 0.01.