Table 3.

Multivariate analysis for determinants of complication rate.

Complication/parameters	RR	95% CI	P
PHT
Age ≥ 35 y	0.798	0.13-4.64	0.801
Splenectomy	0.839	0.27-2.6	0.762
Transfusion	0.670	0.06-6.81	0.735
Hydroxyurea	0.600	0.19-1.82	0.369
Iron chelation	0.160	0.03-0.65	0.011
Cholelithiasis
Age ≥ 35 y	1.153	0.19-6.73	0.874
Female	1.693	0.53-5.34	0.369
Splenectomy	0.140	0.03-0.50	0.003
Transfusion	0.537	0.05-5.27	0.594
Hydroxyurea	0.179	0.05-0.60	0.006
Iron chelation	0.325	0.08-1.19	0.09
Hypothyroidism
Age ≥ 35 y	1.817	0.20-16.14	0.592
Splenectomy	2.178	0.70-6.75	0.178
Transfusion	0.251	0.05-1.24	0.091
Hydroxyurea	0.645	0.23-1.79	0.401
Iron chelation	0.552	0.241-1.265	0.149
Osteoporosis
Age ≥ 35 y	0.616	0.235-1.62	0.364
Female	4.139	0.87-19.58	0.073
Ferritin ≥ 1000 μg/L	6.86	1.09-42.97	0.040
Splenectomy	0.994	0.24-4.11	0.994
Transfusion	14.352	0.86-221.12	0.063
Hydroxyurea	9.004	1.67-48.41	0.010
Iron chelation	0.443	0.09-2.08	0.302