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. 2020 Mar 12;2020(3):CD003965. doi: 10.1002/14651858.CD003965.pub3

Comparison 4. MMF versus no MMF regimen.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 ESKD 4 280 Risk Ratio (IV, Random, 95% CI) 0.73 [0.16, 3.23]
1.1 MMF versus placebo/usual care 2 66 Risk Ratio (IV, Random, 95% CI) 2.37 [0.63, 8.96]
1.2 MMF plus steroid versus steroid alone 1 174 Risk Ratio (IV, Random, 95% CI) 0.20 [0.01, 4.20]
1.3 MMF plus RASi versus RASi alone 1 40 Risk Ratio (IV, Random, 95% CI) 0.22 [0.05, 0.90]
2 Complete remission 4 271 Risk Ratio (IV, Random, 95% CI) 1.05 [0.73, 1.52]
2.1 MMF versus placebo/usual care 3 97 Risk Ratio (IV, Random, 95% CI) 2.02 [0.55, 7.38]
2.2 MMF plus steroid versus steroid alone 1 174 Risk Ratio (IV, Random, 95% CI) 0.99 [0.68, 1.46]
3 Doubling of serum creatinine 2 74 Risk Ratio (IV, Random, 95% CI) 2.01 [0.28, 14.44]
3.1 MMF versus placebo/usual care 1 34 Risk Ratio (IV, Random, 95% CI) 4.45 [0.25, 79.87]
3.2 MMF plus RASi versus RASi alone 1 40 Risk Ratio (IV, Random, 95% CI) 1.0 [0.07, 14.90]
4 Serum creatinine 1   Mean Difference (IV, Random, 95% CI) Totals not selected
5 GFR loss: ≥ 50% 1   Risk Ratio (IV, Random, 95% CI) Totals not selected
5.1 MMF versus placebo/usual care 1   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
6 GFR loss: ≥ 25% 1   Risk Ratio (IV, Random, 95% CI) Totals not selected
6.1 MMF versus placebo/usual care 1   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
7 Annual GFR loss [mL/min/1.73 m2] 1   Mean Difference (IV, Random, 95% CI) Totals not selected
7.1 MMF versus placebo/usual care 1   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
8 GFR (any measure) [mL/min/1.73 m2] 1   Mean Difference (IV, Random, 95% CI) Totals not selected
9 Urinary protein excretion 5 172 Mean Difference (IV, Random, 95% CI) ‐0.06 [‐0.92, 0.81]
9.1 MMF versus placebo 3 92 Mean Difference (IV, Random, 95% CI) 0.59 [0.20, 0.98]
9.2 MMF plus RASi versus RASi alone 1 40 Mean Difference (IV, Random, 95% CI) ‐1.26 [‐1.46, ‐1.06]
9.3 MMF versus leflunomide 1 40 Mean Difference (IV, Random, 95% CI) ‐0.02 [‐0.20, 0.16]
10 Infection 4 301 Risk Ratio (IV, Random, 95% CI) 1.36 [0.87, 2.12]
10.1 MMF versus placebo/usual care 3 126 Risk Ratio (IV, Random, 95% CI) 1.35 [0.50, 3.64]
10.2 MMF plus steroid versus steroid alone 1 175 Risk Ratio (IV, Random, 95% CI) 1.37 [0.83, 2.24]
11 Malignancy 2   Risk Ratio (IV, Random, 95% CI) Subtotals only
11.1 MMF versus placebo/usual care 2 86 Risk Ratio (IV, Random, 95% CI) 0.28 [0.03, 2.54]