Comparison 7. Leflunomide versus no leflunomide regimen.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 ESKD	1		Risk Ratio (IV, Random, 95% CI)	Totals not selected
1.1 Leflunomide plus low dose steroid versus high dose steroid	1		Risk Ratio (IV, Random, 95% CI)	0.0 [0.0, 0.0]
2 Complete remission	4	282	Risk Ratio (IV, Random, 95% CI)	1.08 [0.80, 1.46]
2.1 Leflunomide versus RASi	1	46	Risk Ratio (IV, Random, 95% CI)	1.17 [0.68, 2.00]
2.2 Leflunomide plus low dose steroid versus high dose steroid	2	187	Risk Ratio (IV, Random, 95% CI)	1.00 [0.64, 1.57]
2.3 Leflunomide versus steroid	1	49	Risk Ratio (IV, Random, 95% CI)	1.63 [0.56, 4.70]
3 Doubling of serum creatinine	1		Risk Ratio (IV, Random, 95% CI)	Totals not selected
3.1 Leflunomide plus low dose steroid versus high dose steroid	1		Risk Ratio (IV, Random, 95% CI)	0.0 [0.0, 0.0]
4 Serum creatinine	2	125	Mean Difference (IV, Random, 95% CI)	‐4.29 [‐15.81, 7.24]
5 GFR (any measure)	2	131	Mean Difference (IV, Random, 95% CI)	11.11 [‐3.32, 25.55]
5.1 Leflunomide plus low dose steroid versus high dose steroid	1	85	Mean Difference (IV, Random, 95% CI)	3.77 [‐8.82, 16.36]
5.2 Leflunomide versus RASi	1	46	Mean Difference (IV, Random, 95% CI)	18.5 [5.81, 31.19]
6 Urinary protein excretion	3	125	Mean Difference (IV, Random, 95% CI)	‐0.03 [‐0.32, 0.25]
6.1 Leflunomide plus steroid versus steroid alone	2	85	Mean Difference (IV, Random, 95% CI)	0.03 [‐0.66, 0.72]
6.2 Leflunomide vs MMF	1	40	Mean Difference (IV, Random, 95% CI)	0.02 [‐0.16, 0.20]
7 Infection	3	387	Risk Ratio (IV, Random, 95% CI)	0.97 [0.45, 2.09]
7.1 Leflunomide plus low dose steroid versus high dose steroid	2	187	Risk Ratio (IV, Random, 95% CI)	0.90 [0.41, 1.99]
7.2 Leflunomide versus placebo	1	200	Risk Ratio (IV, Random, 95% CI)	3.0 [0.12, 72.77]