Segarra 2006.

Methods	Study design: parallel, 2‐arm RCT Time frame: not reported Duration of follow‐up: 24 months
Participants	Setting: multicentre (number of sites not reported) Country: Spain Inclusion criteria: IgAN; persistent proteinuria >2.5 g/day; GFR > 30 mL/min; BP < 130/80 mmHg Number (analysed/randomised): treatment group (19/not reported); steroid group (17/not reported) Mean age ± SD (years): not reported Sex (M/F): not reported Exclusion criteria: not reported
Interventions	Treatment group Immunoglobulin: 0.4 g/kg/day administered during 4 consecutive days every month Steroid: 1 mg/kg/d for 4 weeks and then reduced at a rate of 5 mg/day every week until suppression Control group Steroid: 1 mg/kg/d for 4 weeks and then reduced at a rate of 5 mg/day every week until suppression Co‐intervention: not reported
Outcomes	Remission of proteinuria (< 1 g/day) SCr GFR 24 hour proteinuria Serum IgA Complement Secretory IgA IL‐6. IL‐8, MCP‐1, TGF beta Adverse events
Notes	Abstract‐only publication Funding: not reported Trials registration identification number: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information to permit judgement
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	High risk	Open‐label study
Blinding of outcome assessment (detection bias) All outcomes	High risk	Blinding of outcome assessment not specifically reported. Key outcomes were objective laboratory measures and were unlikely to be affected by any knowledge of treatment allocation. Reporting of adverse events may have been influenced by knowledge of treatment allocation
Incomplete outcome data (attrition bias) All outcomes	High risk	Insufficient information to permit judgement
Selective reporting (reporting bias)	High risk	Key outcomes expected for this type of study were not reported
Other bias	High risk	Insufficient information to permit judgement