. 2020 Mar 11;156(5):1–9. doi: 10.1001/jamadermatol.2020.0218

Table 2. Risk of Skin Cancer in Patients With Vitiligo After Long-term NBUVB Phototherapy.

Group	Incidence Rate (95% CI)^a	Events, No.	Population, No.	No. of Person-Years	Univariable Analysis		Multivariable Analysis
Group	Incidence Rate (95% CI)^a	Events, No.	Population, No.	No. of Person-Years	Crude HR (95% CI)	P Value	Adjusted HR (95% CI)^b	P Value
Actinic keratosis
No NBUVB^c	6.1 (4.7-7.7)	65	20 105	106 910	1 [Reference]		1 [Reference]
NBUVB <50^d	5.6 (4.3-7.2)	60	20 106	106 578	0.920 (0.648-1.307)	.64	0.940 (0.662-1.336)	.73
NBUVB 50-99^e	4.3 (2.7-6.4)	23	9702	53 732	0.701 (0.435-1.127)	.14	0.751 (0.467-1.209)	.24
NBUVB 100-199^f	8.4 (5.7-11.9)	31	6226	36 888	1.379 (0.899-2.115)	.14	1.413 (0.921-2.168)	.11
NBUVB ≥200^g	14.2 (10.2-19.4)	40	4182	28 106	2.359 (1.590-3.499)	<.001	2.269 (1.530-3.365)	<.001
Bowen disease
No NBUVB^c	0.7 (0.3-1.3)	7	20 105	107 110	1 [Reference]		1 [Reference]
NBUVB <50^d	0.2 (0-0.7)	2	20 106	106 748	0.283 (0.059-1.360)	.12	0.289 (0.060-1.392)	.12
NBUVB 50-99^e	0.4 (0-1.3)	2	9702	53 795	0.560 (0.116-2.694)	.47	0.603 (0.125-2.904)	.53
NBUVB 100-199^f	0.8 (0.2-2.4)	3	6226	36 992	1.219 (0.315-4.714)	.78	1.273 (0.329-4.924)	.73
NBUVB ≥200^g	0.7 (0.1-2.6)	2	4182	28 260	1.068 (0.221-5.146)	.94	1.021 (0.212-4.919)	.98
Nonmelanoma skin cancer
No NBUVB^c	2.6 (1.7-3.8)	28	20 105	107 025	1 [Reference]		1 [Reference]
NBUVB <50^d	2.3 (1.5-3.5)	25	20 106	106 674	0.889 (0.518-1.525)	.67	0.914 (0.533-1.567)	.74
NBUVB 50-99^e	1.9 (0.9-3.4)	10	9702	53 781	0.705 (0.343-1.452)	.34	0.765 (0.372-1.576)	.47
NBUVB 100-199^f	2.4 (1.1-4.6)	9	6226	36 960	0.924 (0.436-1.959)	.84	0.960 (0.453-2.034)	.91
NBUVB ≥200^g	2.5 (1.0-5.1)	7	4182	28 233	0.940 (0.410-2.153)	.88	0.905 (0.395-2.073)	.81
Melanoma
No NBUVB^c	1.3 (0.7-2.2)	14	20 105	107 090	1 [Reference]		1 [Reference]
NBUVB <50^d	0.8 (0.4-1.6)	9	20 106	106 736	0.649 (0.281-1.500)	.31	0.660 (0.286-1.526)	.33
NBUVB 50-99^e	1.1 (0.4-2.4)	6	9702	53 772	0.862 (0.331-2.243)	.76	0.907 (0.348-2.362)	.84
NBUVB 100-199^f	0.8 (0.2-2.4)	3	6226	36 991	0.632 (0.182-2.200)	.47	0.648 (0.186-2.255)	.50
NBUVB ≥200^g	0.7 (0.1-2.6)	2	4182	28 254	0.559 (0.127-2.460)	.44	0.539 (0.122-2.374)	.41

Abbreviations: HR, hazard ratio; NBUVB, narrowband UV-B.

^{^a}

Incidence rate per 10 000 person-years.

^{^b}

Adjusted by age and sex.

^{^c}

Patients who had not received phototherapy.

^{^d}

Patients who had received less than 50 sessions.

^{^e}

Patients who had received 50 to 99 sessions.

^{^f}

Patients who had received 100 to 199 sessions.

^{^g}

Patients who had received 200 or more sessions.