. 2020 Mar 11;156(5):1–9. doi: 10.1001/jamadermatol.2020.0218

Table 3. Subgroup Analyses of the Association of Risk of Skin Cancer With Long-term NBUVB Phototherapy by Sex and Age.

Group	Male		Female		Aged 20-49 y		Aged ≥50 y
Group	Adjusted HR (95% CI)^a	P Value	Adjusted HR (95% CI)^a	P Value	Adjusted HR (95% CI)^a	P Value	Adjusted HR (95% CI)^a	P Value
Actinic keratosis
No NBUVB^b	1 [Reference]		1 [Reference]		1 [Reference]		1 [Reference]
NBUVB <50^c	1.353 (0.768-2.383)	.30	0.744 (0.472-1.174)	.20	1.953 (0.358-10.665)	.44	0.910 (0.635-1.305)	.61
NBUVB 50-99^d	0.940 (0.414-1.974)	.80	0.678 (0.372-1.238)	.21	1.911 (0.269-13.573)	.52	0.717 (0.437-1.175)	.19
NBUVB 100-199^e	1.937 (0.970-3.871)	.06	1.158 (0.669-2.004)	.60	5.759 (1.054-31.451)	.04	1.276 (0.813-2.004)	.29
NBUVB ≥200^f	2.638 (1.360-5.120)	.004	2.099 (1.284-3.431)	.003	20.529 (4.488-93.915)	<.001	1.747 (1.131-2.699)	.01
Bowen disease
No NBUVB^b	1 [Reference]		1 [Reference]		1 [Reference]		1 [Reference]
NBUVB <50^c	0.335 (0.035-3.221)	.34	0.255 (0.028-2.281)	.22	0 (NA)	.99	0.339 (0.068-1.680)	.19
NBUVB 50-99^d	0.701 (0.073-6.741)	.76	0.531 (0.059-4.753)	.57	0 (NA)	.99	0.710 (0.143-3.517)	.68
NBUVB 100-199^e	2.039 (0.340-12.211)	.44	0.708 (0.079-6.340)	.76	0 (NA)	.99	1.492 (0.373-5.967)	.57
NBUVB ≥200^f	2.302 (0.384-13.803)	.36	0 (NA)	>.99	0 (NA)	.99	1.184 (0.239-5.872)	.84
Nonmelanoma skin cancer
No NBUVB^b	1 [Reference]		1 [Reference]		1 [Reference]		1 [Reference]
NBUVB <50^c	0.744 (0.299-1.849)	.52	1.025 (0.523-2.007)	.94	0.973 (0.137-6.910)	.98	0.907 (0.518-1.590)	.73
NBUVB 50-99^d	0.972 (0.338-2.797)	.96	0.630 (0.233-1.709)	.37	1.899 (0.267-13.492)	.52	0.664 (0.301-1.468)	.31
NBUVB 100-199^e	1.733 (0.640-4.688)	.28	0.498 (0.146-1.700)	.27	1.377 (0.125-15.199)	.79	0.924 (0.418-2.042)	.85
NBUVB ≥200^f	1.639 (0.569-4.722)	.36	0.430 (0.099-1.863)	.26	0 (NA)	.99	0.976 (0.424-2.250)	.96
Melanoma
No NBUVB^b	1 [Reference]		1 [Reference]		1 [Reference]		1 [Reference]
NBUVB <50^c	0.635 (0.208-1.941)	.43	0.695 (0.196-2.467)	.57	0.976 (0.197-4.835)	.98	0.572 (0.211-1.547)	.27
NBUVB 50-99^d	0.784 (0.208-2.954)	.72	1.076 (0.269-4.313)	.92	0.670 (0.070-6.444)	.73	0.993 (0.345-2.860)	.99
NBUVB 100-199^e	0.382 (0.048-3.055)	.36	0.995 (0.201-4.937)	>.99	0 (NA)	.99	0.840 (0.234-3.015)	.79
NBUVB ≥200^f	0.468 (0.059-3.748)	.51	0.631 (0.076-5.248)	.67	1.283 (0.133-12.371)	.83	0.336 (0.043-2.605)	.30

Abbreviations: HR, hazard ratio; NA, not applicable; NBUVB, narrowband UV-B.

^{^a}

Adjusted by age and sex.

^{^b}

Patients who had not received phototherapy.

^{^c}

Patients who had received less than 50 sessions.

^{^d}

Patients who had received 50 to 99 sessions.

^{^e}

Patients who had received 100 to 199 sessions.

^{^f}

Patients who had received 200 or more sessions.