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. 2020 Mar 5;11:188. doi: 10.3389/fphar.2020.00188

Figure 4.

Figure 4

U50,488 and LOR17-mediated phospho-p38MAPK (P-p38) increase in HEK-293/hKOPr cells, U87-MG astrocytoma cells and normal human astrocytes. (A). Representative blots and quantification of P-p38 levels in HEK-293/hKOPr cells exposed to U50,488 (1 µM; 30 min), LOR17 (1 µM; 30 min) or vehicle; data are presented as the mean ± SD of 6 independent experiments. *p < 0.05 vs vehicle (Newman-Keuls test after ANOVA). (B, C). Representative blots and quantification of P-p38 levels in U87-MG human astrocytoma cells exposed to 1 µM U50,488, 1 µM LOR17 or vehicle; data are presented as the mean ± SD of 6 independent experiments. *p < 0.05 vs vehicle (Newman-Keuls test after ANOVA). (D, E). Representative blots and quantification of P-p38 levels in normal human astrocytes exposed to 1 µM U50,488, 1 µM LOR17 or vehicle; data are presented as the mean ± SD of 6 independent experiments. *p < 0.05 vs vehicle (Newman-Keuls test after ANOVA).