Table 1.

In vitro affinity of LOR17 and reference compounds to opioid receptors.

Compound	Sequence	Ki MOR (nM)	Ki DOR (nM)	Ki KOR (nM)
DAMGO	H-Tyr-D-Ala-Gly-NMePhe-Glyol	1.5 ± 0.1
DPDPE	H-Tyr-c[D-Pen-Gly-Phe-D-Pen]-OH		3.30 ± 0.05
U50,488	not peptide			2.90 ± 0.04
LOR17	c[Phe-Gly-(β-Ala)-D-Trp]	>105	>105	1.19 ± 0.28

Mean of 6 determinations ± SD.