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Inhibitory effects of LOR17 and U50,488 on forskolin-induced cAMP accumulation in different cell models.
| COMPOUND | IC50 HEK-293/KOR (nM) | EmaxHEK-293/KOR (%) | IC50 U87-MG (nM) | EmaxU87-MG (%) | IC50 NHA (nM) | EmaxNHA(%) |
|---|---|---|---|---|---|---|
| U50,488 | 1.6 ± 0.5 | 90 ± 2 | 1.2 ± 0.2 | 88 ± 3 | 2.2 ± 0.4 | 87 ± 3 |
| LOR17 | 2.8 ± 0.6 | 85 ± 5 | 3.1 ± 0.8 | 87 ± 4 | 3.0 ± 0.2 | 88 ± 6 |
Mean ± SD of 6 independent experiments performed in triplicate.
