| Methods |
Randomised
Double‐blinded
ITT |
| Participants |
n = 261
Heartburn
No oesophagitis |
| Interventions |
Four weeks
OME 20 mg
OME 10 mg
Placebo |
| Outcomes |
Symptom relief
Symptom control
Quality of life |
| Notes |
ENRD |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Insufficient information about the sequence generation process to permit judgement. |
| Allocation concealment (selection bias) |
Unclear risk |
Method of concealment not described. |
| Blinding (performance bias and detection bias)
All outcomes |
Unclear risk |
"Double blind treatment" stated, unclear how it was performed, insufficient information to permit judgement. |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
Missing outcome data balanced in numbers across intervention groups, with similar reasons for missing data across groups. |
| Selective reporting (reporting bias) |
Unclear risk |
Unclear |
| Other bias |
Unclear risk |
Unclear |
