| Methods |
Randomised
Double‐blinded
ITT(m) |
| Participants |
n = 423
Two of the following: heartburn, epigastric pain, regurgitation
No oesophageal ulcer |
| Interventions |
Two weeks
RAN 150 mg bid
Placebo |
| Outcomes |
Complete symptom relief
Improvement |
| Notes |
GORD |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Sequence generation process not described. |
| Allocation concealment (selection bias) |
Unclear risk |
Method of concealment not described. |
| Blinding (performance bias and detection bias)
All outcomes |
Unclear risk |
Double‐blinded was stated, but method was not described. |
| Incomplete outcome data (attrition bias)
All outcomes |
High risk |
After randomisation 4 of 427 withdrew and were not analysed or accounted for |
| Selective reporting (reporting bias) |
Unclear risk |
Unclear |
| Other bias |
Unclear risk |
Unclear |
