Kahrilas 2005.

Methods	Randomised Double‐blinded ITT
Participants	n = 261 Heartburn No oesophageal erosions
Interventions	Four weeks RAB 20 mg Placebo
Outcomes	Complete heartburn relief Marked improvement Satisfactory daytime/night time relief
Notes	ENRD
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information about the sequence generation process to permit judgement.
Allocation concealment (selection bias)	Unclear risk	The method of concealment not described.
Blinding (performance bias and detection bias) All outcomes	Low risk	"Trial participants and administering physicians were blinded as to whether patients were taking active drug or placebo. Any patients for whom the blinding code was broken because of an emergency were removed from the trial."
Incomplete outcome data (attrition bias) All outcomes	Low risk	"The integrated analysis included all intent‐to‐treat (ITT) patients who received rabeprazole 20 mg once daily or placebo from the 2 studies." Missing outcome data balanced in numbers across intervention groups, with similar reasons for missing data across groups.
Selective reporting (reporting bias)	Unclear risk	Unclear
Other bias	Unclear risk	Unclear