| Methods |
Randomised
Double‐blinded
ITT |
| Participants |
n = 590
Heartburn |
| Interventions |
Six weeks
RAN 150 mg
Placebo |
| Outcomes |
Heartburn‐free
Improvement
Quality of life |
| Notes |
GORD |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Randomisation was determined by a computerised random table |
| Allocation concealment (selection bias) |
Unclear risk |
Method of concealment allocation not described |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
"Investigators were blinded to the study medications, which were formulated and packaged" |
| Incomplete outcome data (attrition bias)
All outcomes |
High risk |
"Of these, 590 patients comprise the per‐protocol database" |
| Selective reporting (reporting bias) |
Unclear risk |
Unclear |
| Other bias |
Unclear risk |
Unclear |
