| Methods |
Randomised
Double‐blinded
Per Protocol |
| Participants |
n = 54
Heartburn, regurgitation or dysphagia
No oesophagitis |
| Interventions |
Two weeks
OME 40 mg
Placebo |
| Outcomes |
Symptom improvement |
| Notes |
ENRD |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Sequence generation process not described |
| Allocation concealment (selection bias) |
Unclear risk |
Method of concealment allocation not described |
| Blinding (performance bias and detection bias)
All outcomes |
Unclear risk |
Double‐blinded was stated, but the method was not described. |
| Incomplete outcome data (attrition bias)
All outcomes |
High risk |
"Thirteen subjects ... had to be withdrawn from further analysis" |
| Selective reporting (reporting bias) |
Unclear risk |
Unclear |
| Other bias |
Unclear risk |
Unclear |
