Cohn 1984 b.

Methods	RCT Double Blind Concealment of allocation unclear Analysis: Endpoint Duration: 28 days
Participants	Diagnosis Major Depressive Disorder DSMIII and HAM‐D > 20 Outpatients N= 63 Sex 23M, 40F Mean age = ˜66
Interventions	1. Placebo N=21 2. Imipramine N‐21 75mg/d to 200mg/d split dose 3. Nomifensine N=21 75mg/d to 200mg/d split dose
Outcomes	HAM‐D CGI Hopkins symptom Checklist BPRS
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear