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. 2001 Jan 22;2001(1):CD000561. doi: 10.1002/14651858.CD000561

De Leo 1984.

Methods RCT 
 Concealment of allocation unclear 
 Blindness double 
 Duration 28 days
Participants Diagnosis Primary Depression DSMIII 
 Symptoms present > 5 months 
 Institution for elderly 
 N= 46 
 Sex 8M, 16F 
 Mean age=74.79+9.51
Interventions 1 Placebo N=22 
 2. Viloxazine N=24 
 200mg/d to 300mg/d in split dose
Outcomes Zung SDS 
 HAM‐D 
 CGI 
 TESS
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear