Skip to main content
. 2001 Jan 22;2001(1):CD000561. doi: 10.1002/14651858.CD000561

Kane 1983.

Methods RCT 
 Concealment of allocation unclear 
 Blindness double 
 Duration 28 days
Participants Diagnosis depressed mood and 4 associated symptoms HAM‐D >18 
 Outpatients (Psych) 
 N=44 
 Sex 13M, 31F 
 Mean age = 63.9+6.98
Interventions 1. Placebo N=7 
 2. Bupropion (LD)N =11 
 150mg/d 
 3. Bupropion (HD)N=13 
 300mg/d 
 4. Imipramine N=13 
 75‐200mg/d
Outcomes HAM‐D 
 HAMA 
 CGI 
 Zung SDS 
 Zung SAS
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear