Skip to main content
. 2001 Jan 22;2001(1):CD000561. doi: 10.1002/14651858.CD000561

Nair 1995.

Methods RCT 
 Concealment of allocation unclear 
 Blindness double 
 Duration 49 days
Participants Diagnosis Major Depressive Disorder DSMIIIR 
 HAM‐D >18 
 CGI >Moderate 
 Unknown recruitment 
 N=109 
 Sex 32M, 77F 
 Mean age = ˜69
Interventions 1. Placebo N=35 
 2. Moclobemide N=36 
 100 ‐400mg/d 
 3. Nortriptyline N=38 
 25 ‐75mg/d to serum levels 50‐170ng/ml
Outcomes GDS 
 HAM‐D 
 CGIS 
 MMSE 
 CGIE 
 CGIT
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear