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. 2001 Jan 22;2001(1):CD000561. doi: 10.1002/14651858.CD000561

Parnetti 1991.

Methods RCT 
 Concealment of allocation unclear 
 Blindness double 
 Duration 49 days
Participants Diagnosis Prolonged Reactive Depression ICD9 
 MMSE >25 
 Outpatients (Psych) 
 N=130 
 Sex 47M, 83F 
 Mean age = ˜71
Interventions 1. Placebo N=67 
 2. Minaprine N=63 
 200mg/d
Outcomes Evaluation Clinque de la Personalitie 
 Symptom Rating Test 
 CGI
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear