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. 2001 Jan 22;2001(1):CD000561. doi: 10.1002/14651858.CD000561

Tollefson 1993.

Methods RCT 
 Concealment of allocation unclear 
 Blindness double 
 Duration 42 days
Participants Diagnosis Unipolar Major Depression DSMIIIR 
 HAM‐D >16 
 Outpatients 
 N=671 
 Sex 305M, 366 
 Mean age = 67.7 +7.7
Interventions 1. Placebo N=336 
 2. Fluoxetine N=335 
 20mg/d or every other day
Outcomes HAM‐D 
 SF‐36 
 CGI 
 PGI
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear