Table 3. Stability of Selegiline in Rat Plasmae.
| nominal concentration (ng/mL) | autosamplera stability (%) | short-termb stability (%) | long-termc stability (%) | freeze–thawd stability (%) |
|---|---|---|---|---|
| 5 | 89.83 ± 3.86 | 90.43 ± 2.57 | 88.63 ± 2.32 | 66.36 ± 1.79 |
| 50 | 100.1 ± 6.97 | 91.19 ± 7.33 | 87.75 ± 1.44 | 59.40 ± 0.68 |
| 500 | 96.43 ± 8.44 | 83.43 ± 8.81 | 88.69 ± 3.41 | 67.27 ± 1.42 |
Autosampler stability: the sample was placed in an autosampler at 10 °C for 6 h.
Short-term stability: the sample was placed in plasma at 4 °C for 6 h.
Long-term stability: the sample was placed in plasma at −20 °C for 2 weeks.
Freeze–thaw stability: the sample was placed in plasma at −20 °C for 12 h and then at room temperature for 12 h, and this cycle was repeated three times.
Formulation = (peak area of processed sample/peak area of freshly prepared sample) × 100.