Table 1.
All (n = 62) | DR (n = 11) | True PD (n = 51) | P | ||||
---|---|---|---|---|---|---|---|
n | n | % | n | % | |||
Age | median 65, range 27–82 | ||||||
≥75 | 11 | 2 | 18 | 9 | 18 | 1.000 | |
< 75 | 51 | ||||||
Gender | Male | 40 | 7 | 64 | 33 | 65 | 1.000 |
Female | 22 | ||||||
Performance status | 0,1 | 46 | 8 | 73 | 38 | 75 | 1.000 |
2–4 | 16 | ||||||
Smoking status | Current/former | 45 | 6 | 55 | 39 | 76 | 0.155 |
Never | 17 | ||||||
Histology | Squamous cell carcinoma | 12 | 2 | 18 | 10 | 20 | 1.000 |
Non-squamous cell carcinoma | 50 | ||||||
Adenocarcinoma (n = 46), Others (n = 4) | |||||||
Driver mutation | Positive | 15 | 3 | 27 | 12 | 24 | 0.696 |
EGFR L858R/19del (n = 12), ALK (n = 3) | |||||||
Negative | 47 | ||||||
Line of treatment | 2nd line | 32 | 7 | 64 | 25 | 49 | 0.511 |
3rd line or beyond | 30 | ||||||
PD-L1 status | < 1 | 8 | 0 | 0 | 8 | 16 | |
1 ≤ | 28 | 7 | 64 | 21 | 41 | ||
Unknown | 26 | 4 | 40 | 22 | 43 | ||
Treatment | Nivolumab | 45 | 9 | 20 | 36 | 80 | |
Pembrolizumab | 7 | 2 | 29 | 5 | 71 | ||
Atezolizumab | 10 | 0 | 0 | 10 | 100 |
Abbreviations: DR dissociated responses, PD-L1 programmed cell death-ligand 1, True PD true progressive disease