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. 2020 Mar 12;15:24. doi: 10.1186/s13020-020-00306-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Network construction and pathway and functional enrichment analysis of the effect of JSD on DN. a Potential active ingredient-target-disease network. The different colors of the symbols represent the following: disease (red), herb names (green), targets (blue) and compounds (purple). b PPI network. The following nodes are shown: query proteins and direct interactors (colored nodes), secondary interactors (white nodes), proteins with unknown 3D structure (empty nodes), proteins with known or predicted 3D structure (filled nodes) from curated databases ( ), experiments ( ), gene neighborhood ( ), gene fusions ( ), gene cooccurrence ( ), text mining ( ), coexpression ( ), and protein homology ( ). c Frequency analysis of protein targets. d KEGG pathway enrichment analysis. The gradual change in color represents the change in probability. e GO function analysis. The gradual change in color represents the change in probability

Inline graphic — Network construction and pathway and functional enrichment analysis of the effect of JSD on DN. a Potential active ingredient-target-disease network. The different colors of the symbols represent the following: disease (red), herb names (green), targets (blue) and compounds (purple). b PPI network. The following nodes are shown: query proteins and direct interactors (colored nodes), secondary interactors (white nodes), proteins with unknown 3D structure (empty nodes), proteins with known or predicted 3D structure (filled nodes) from curated databases ( ), experiments ( ), gene neighborhood ( ), gene fusions ( ), gene cooccurrence ( ), text mining ( ), coexpression ( ), and protein homology ( ). c Frequency analysis of protein targets. d KEGG pathway enrichment analysis. The gradual change in color represents the change in probability. e GO function analysis. The gradual change in color represents the change in probability