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Biosynthetic and signaling pathways for N-acyl-ethanolamides (NAEs). Phosphatidylethanolamine (PE) N-acyltransferase enzymes transfer an acyl chain from a donor phospholipid to PE to form N-acyl-phosphatidylethanolamines (NAPE) which are then converted by NAPE hydrolyzing phospholipase D (NAPE-PLD) to NAEs, which in mammals act on receptors including PPARα, GPR119, GPR55, and TRPV1.
