Table 2.
Binary Logistic Regression Models for Favorable Three-month Functional Outcome (mRS 0-3)
| Variables with univariate p<0.25 | Fully Adjusted Model | Parsimonious Model | Parsimonious Model with Hematoma Burden Variables Reintroduced | ||||||
|---|---|---|---|---|---|---|---|---|---|
| All subarachnoid hemorrhage | |||||||||
| OR | 95% CI | p | OR | 95% CI | p | OR | 95% CI | p | |
| Seven-day average CSF protein (75th versus 25th percentile) | 0.484 | 0.244-0.902 | 0.02 | 0.392 | 0.232-0.696 | 0.001 | 0.392 | 0.220-0.696 | 0.002 |
| Admission GCS score | 1.28 | 1.12-1.47 | <0.001 | 1.23 | 1.10-1.37 | <0.001 | 1.23 | 1.10-1.39 | 0.001 |
| Parenchymal hematoma present† | 0.207 | 0.048-0.902 | 0.04 | 0.159 | 0.040-0.635 | 0.009 | 0.155 | 0.037-0.647 | 0.01 |
| Seven-day average CSF | 1.00 | 1.00-1.00 | 0.46 | -- | -- | -- | 1.00 | 1.00-1.00 | 0.77 |
| RBCs (75th versus 25th percentile) | -- | -- | -- | 1.00 | 1.00-1.00 | 0.73 | |||
| IVH Volume (mL) | 1.00 | 1.00-1.00 | 0.76 | -- | -- | -- | 0.918 | 0.388-2.18 | 0.85 |
| Modified Fisher CT Score | 1.02 | 0.415-2.50 | 0.97 | -- | -- | -- | -- | -- | -- |
| Age (years) | 0.973 | 0.933-1.02 | 0.21 | -- | -- | -- | -- | -- | -- |
| Seven-day average CSF WBCs (75th versus 25th percentile) | 1.10 | 0.81-1.50 | 0.53 | ||||||
| WBCs (75th versus 25th percentile) | -- | -- | -- | -- | -- | -- | |||
| Perimesencephalic SAH | >1000 | 0.00->1000 | 1.00 | -- | -- | -- | -- | -- | -- |
| History of Diabetes Mellitus | 0.538 | 0.099-2.93 | 0.47 | ||||||
| Aneurysm subarachnoid hemorrhage only | |||||||||
| OR | 95% CI | p | OR | 95% CI | p | OR | 95% CI | p | |
| Seven-day average CSF protein (75th versus 25th percentile) | 0.474 | 0.250-0.898 | 0.02 | 0.426 | 0.245-0.740 | 0.002 | 0.392 | 0.220-0.733 | 0.002 |
| Admission GCS score | 1.28 | 1.12-1.47 | <0.001 | 1.24 | 1.01-1.40 | <0.001 | 1.26 | 1.10-1.43 | <0.001 |
| Parenchymal hematoma present | 0.207 | 0.048-0.902 | 0.04 | 0.186 | 0.046-0.749 | 0.02 | 0.195 | 0.047-0.813 | 0.02 |
| Seven-day average CSF | 1.00 | 1.00-1.00 | 0.47 | -- | -- | -- | 1.00 | 1.00-1.00 | 0.53 |
| RBCs (75th versus 25th percentile) | -- | -- | -- | 1.00 | 1.00-1.00 | 0.74 | |||
| IVH Volume (mL) | 1.00 | 1.00-1.00 | 0.82 | -- | -- | -- | 1.03 | 0.425-2.50 | 0.95 |
| Modified Fischer CT Score | 1.02 | 0.415-2.50 | 0.97 | -- | -- | -- | -- | -- | -- |
| Age (years) | 0.973 | 0.933-1.02 | 0.21 | -- | -- | -- | -- | -- | -- |
| Seven-day average CSF | 1.10 | 0.81-1.50 | 0.53 | ||||||
| WBCs (75th versus 25th percentile) | -- | -- | -- | -- | -- | -- | |||
| History of Diabetes Mellitus | 0.538 | 0.099-2.93 | 0.47 | ||||||
GCS was used as the clinical severity variable for modeling since it had the strongest univariate test statistic and is colinear with WFNS score, Hunt Hess scale, and NIHSS score.
The odds ratios for continuous variables represent the odds ratio associated with a one-unit change in the variable unless otherwise listed parenthetically.
Equivalent to a parsimonious model odds ratio of 6.31 (95% CI 1.58–25.25) for parenchymal hematoma presence predicting unfavorable outcome
CI = confidence interval, CSF = cerebrospinal fluid, GCS = Glasgow Coma Scale, IVH =intraventricular hemorrhage OR = Odds Ratio, RBCs = red blood c1ells, SAH = subarachnoid hemorrhage WBCs = white blood cells