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. Author manuscript; available in PMC: 2020 Mar 12.
Published in final edited form as: Nature. 2020 Feb 5;578(7794):273–277. doi: 10.1038/s41586-020-1984-7

Extended Data Fig. 8 |. Reaction scheme for the chemical synthesis of HS-199.

Extended Data Fig. 8 |

HS-199 was synthesized by mixing 0.462 mM methyl 5′-bromo-[2,2′- bithiophene]-5-carboxylate with 0.508 mM (5-formylthiophen-2-yl)boronic acid, K2CO3 (1.39 mmol) in 1,4-dioxane/methanol (8: 2, 8 mL/mM, degassed) and PEPPS-IPr (2 mol %).