Table 3. Cytotoxic activity of paclitaxel combined with EM-E-11-4 against A549/Tax (P-gp siRNA) and Hela/βIII (TUBB3 siRNA) cell lines.

Compound	IC50 (nM, Mean ± SD)		IC50 (nM, Mean ± SD)
	A549/Tax		Hela/βIII
	NC	P-siRNA	NC	T-siRNA
Paclitaxel	1498±35	24.4±3.6	48.7±4.3	2.4±0.3
Paclitaxel + EM-E-11-4 10μM	25.4±3.2	22.5±2.7	2.1±0.4	2.3±0.4

Data are presented as mean ± SD from three independent experiments.