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. 2020 Feb 22;12(4):3451–3472. doi: 10.18632/aging.102821

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Copyright © 2020 Li et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Clinical relevance of TLS in training cohort and validation cohort subgroups. (A–D) Kaplan–Meier curves showing that in patients with BCLC 0-A stage HCC, TLS+ was correlated to similar OS, better RFS, better early RFS and similar late RFS compared to those with TLS-; (E–H) Kaplan–Meier curves showing no significant correlation between TLS and OS, RFS, early RFS and late RFS for patients with BCLC B-C stage HCC; (I–L) Kaplan–Meier curves showing patients with TLS+ had similar OS, better RFS, better early RFS and similar late RFS compared to those with TLS- in the validation cohort. TLS, tertiary lymphoid structures; OS, overall survival; RFS, recurrence-free survival; BCLC, Barcelona Clinic of Liver Cancer.